Disease and Research Knowledge

TRiNDS was formed by colleagues at several academic centers that are part of the CINRG network. The TRiNDS team builds on the strong leadership skills developed by the CINRG consortium. It is focused on providing efficient services to pharmaceutical and biotechnology industries as well as academic investigators. TRiNDS combines international disease expertise with regulatory agency compliant data and project management solutions as well as study design, biostatistical analyses and interpretation.

With the knowledge obtained from running the CINRG coordinating center for over a decade, the TRiNDS team has established methods for:

  • Running clinical research studies of phases, pilot through post-marketing
  • Master contracting and budgeting with clinical sites
  • Streamlined ethics approval processes
  • Regulatory compliant document tracking with a full-service clinical trial management software
  • Published domain expertise in sensitivity and reliability of clinical and quality of life endpoints
  • Standard operating procedures (SOPs) for clinical trial operations
  • Semi-automated data collection and transmission to the central management site
  • Standardized training and reliability assessments for clinical outcome measures
  • Regulatory agency compliant electronic data capture (EDC)
  • Specialized statistical expertise for robust analyses of collected data
  • Standing independent data and safety monitoring board (DSMB)

These services with the domain expertise and research knowledge fill an emerging need in drug development for rare and orphan disease such as neuromuscular diseases.

The TRiNDS team has experience in the following neuromuscular diseases:

  • Duchenne muscular dystrophy (DMD)
  • Becker muscular dystrophy (BMD)
  • Facioscapulohumeral muscular dystrophy (FSHD)
  • Limb girdle muscular dystrophy (LGMD)