Study Measurements

TRiNDS is a specialized contract research organization (CRO) leveraging experience in Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), Pompe Disease, and other neuromuscular disorders. TRiNDS Study Measurements team is staffed by subject matter experts who help select, implement, control, and interpret neuromuscular study measurements. Our team of rare disease and neuromuscular experts help clients select the most appropriate study measurements for the trial population and their expected disease progression.

TRiNDS clinical evaluations managers are specialized in neuromuscular and rare diseases.

We offer support for:

  • Functional outcome measure selection
  • Study manual development
  • Site clinical evaluator qualification, training, and re-training
  • Functional testing supply management
  • Central data monitoring and quality control of selected measures
  • Interpretation of study measurement results and publication assistance

We offer support for outcome measures relevant to the entire neuromuscular disease spectrum including:

  • Biomarkers and genetic modifiers
  • Strength and function measures such as:
    • Timed function tests like the time to stand, time to climb 4 stairs, or time to run/walk
    • North Star Ambulatory Assessment (NSAA)
    • Six-minute walk test (6MWT)
    • Performance of the Upper Limb
    • Manual muscle testing
    • Handheld Myometry
    • Nine Hole Peg Test
    • Brooke Scale
    • Vignos Scale
    • Egen Klassification
  • Pulmonary function and respiratory strength such as:
    • Spirometry (FVC, PEF, FEV, PCF)
    • Maximum Inspiratory Pressure, Maximum Expiratory Pressure, Sniff Nasal Inspiratory Pressure
  • Cardiac function
  • Patient reported outcomes such as:
    • Pediatric Quality of Life Inventory (PedsQL)
    • Pediatric Orthopaedic Functional Health Questionnaire of the Pediatric Orthopaedic Society of North America (POSNA)
    • World Health Organization Quality of Life Assessment – Brief (WHO QOL Brief)
    • Pediatrics and Adult Neuromuscular module Quality of Life (NeuroQOL)
  • Community based outcome measures such as:
    • Actigraph

Contact us today to learn how TRiNDS can support your development goals.