TRiNDS Study Measurements

Under the direction of TRiNDS Strategic Solutions, Study Measurements provides subject matter experts who help select, implement, control, and interpret neuromuscular study measurements. Our team of rare disease and neuromuscular experts help clients select and implement the most appropriate study measurements for the trial population and their expected disease progression. TRiNDS clinical evaluations managers are specialized in neuromuscular and rare diseases.

We offer support for:

Outcome measure selection and validation
Study manual development
Site clinical evaluator qualification, training, and re-training
Supply and equipment procurement and management
Central data monitoring and quality control of selected measures
Interpretation of study measurement results and publication assistance

We offer support for outcome measures relevant to the entire neuromuscular disease spectrum including:

Biomarkers and genetic modifiers
Strength and function measures such as:
- Timed function tests (time to stand, time to climb 4 stairs, time to run/walk)
- North Star Ambulatory Assessment (NSAA)
- Six-minute and 2-minute walk tests, 100 meter walk/run test
- Performance of the Upper Limb
- Manual muscle testing and Handheld myometry
- Nine Hole Peg Test
- Brooke & Vignos Extremity Scales
- Egen Klassification Scale
Pulmonary function and respiratory strength such as:
- Spirometry (FVC, PEF, FEV, PCF)
- Maximum Inspiratory Pressure, Maximum Expiratory Pressure, Sniff Nasal Inspiratory Pressure
- Cardiac function
- Patient reported outcomes
- Wearables and community based outcome measures such as Actigraph